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Evaluation of Prevalence of Colorectal Cancer and Polyps in Relatives of Patients with Colorectal Cancer Referring to Colorectal Cancer Registry and Screening Center in west of Iran during 2012-2016
Halimi, Leyla, Ghobakhlou, Mehdi
Background: Colorectal cancer (CRC) is a common, fatal and preventable disease. Given the long interval between the onset of pathological changes and the appearance of clinical symptoms, screening of CRC in high-risk groups plays an important role in early detection of the disease. This study aimed to determine the frequency of CRC and colorectal polyps in first-degree relatives of CRC patients.
Methods: In this descriptive and analytical study, the medical records of all patients referring to the CRC Registry and Screening Center of Hospital of west of Iran from April 2012 to April 2016 were evaluated in terms of demographic characteristics and screening results. In addition, data analysis was performed in SPSS version 16.
Results: In total, 230 colonoscopy cases were identified, 102 of whom (44.3%) were male and 122 (53%) were female. The mean and standard deviation of age was 43.54±10.79 years, where the minimum and maximum ages were reported at 18 and 79 years, respectively. In addition, the prevalence of colorectal polyps and tumors was 14.81% and 0.4%, respectively. The frequency of colorectal polyps divided into subcategories was 48% tubular, 10% villous, 36% hyperplastic, and 4% inflammatory. On the other hand, the sites of polyps were the secum (2.7%), ascending colon (10.8%), transverse colon (1.8%), descending colon (24.4%), hepatic flexure (8.1%), sigmoid colon (13.5%), and rectum (21.6%). Results were indicative of no statistically significant difference between male and female patients in term of polyp frequency. Nonetheless, the frequency of the tubular type of polyp was significantly higher, compared to the other types of polyp and age of ≥40 years (P<0.05).
Conclusion: According to the results of the study, timely colonoscopy is effective in early diagnosis of polyps. In other words, timely detection of CRC can be effective in its treatment.
Keywords: Colorectal Cancer, Polyps, Screening, ColonoscopyView items...